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KMID : 1103720180780010001
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Journal of the Korean Society of Radiology
2018 Volume.78 No. 1 p.1 ~ p.12
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Quantitative CT Imaging in Chronic Obstructive Pulmonary Disease: Review of Current Status and Future Challenges
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Cho Young-Hoon
Seo Joon-Beom
Lee Sang-Min
Choe Joo-Ae
Lee Da-Bee
Kim Nam-Kug
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Abstract
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Chronic Obstructive Pulmonary Disease (COPD) is a complex heterogeneous condition with various clinical and pathologic features. In recent years, technical advances in quantitative CT imaging have generated considerable interest because they can provide a more precise and objective assessment of COPD. Emphysema and small-airway disease, the two major components of COPD, and other comorbidities, including pulmonary vessel alterations, atherosclerosis, cachexia, and osteoporosis, can all be assessed by means of quantitative imaging parameters. Increasing numbers of studies provide promising reports indicating that such parameters are associated with clinical measures of disease severity, respiratory symptoms, COPD exacerbations, and mortality. Despite such optimistic results, there are still many obstacles to using this quantitative technology in everyday practice to manage COPD patients. In this article, we review the current technical status of quantitative CT assessment, emphasizing its clinical implications and limitations. We also discuss present challenges and the potential future role of quantitative CT imaging in assessing COPD.
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KEYWORD
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Chronic Obstructive Lung Disease, Quantitative Evaluation, Emphysema, Airway Remodelling
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